The two years line is equivalent to journal impact factor ™ (Thomson Reuters) metric. Ratio of a journal's items, grouped in three years windows, that have been cited at least once vs. those not cited during the following year. Natural Product Reports, Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. Rankings are updated daily for previous 30 days (below) and previous 12 months. Select a subject area to discover related terms and applicable articles. Please reconnect, Bioinformatics and computational biology (15), Single photon emission computed tomography (6), Nuclear magnetic resonance spectroscopy (8), Electron paramagnetic resonance spectroscopy (2), Fluorescence resonance energy transfer (13), Liquid chromatography-mass spectrometry (1), Chemical engineering and industrial chemistry, Earth, space, and environmental chemistry, Novel 2-Aryloxazoline Compounds Exhibit an Inhibitory Effect on, Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity, Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials, Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides, Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer, Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors, Special Issue - Women in Medicinal Chemistry, Special Issue - In Memory of Maurizio Botta: His Vision of Medicinal Chemistry, Special Issue - Medicinal Chemistry: From Targets to Therapies, Novel Betulinic Acid–Nucleoside Hybrids with Potent Anti-HIV Activity, Challenges and Opportunities for Drug Discovery in Developing Countries: The Example of Cutaneous Leishmaniasis, Novel Bicyclic Heteroaryl Compounds as γ-Secretase Modulators for Treating Alzheimer’s Disease, Discovery of SHR0687, a Highly Potent and Peripheral Nervous System-Restricted KOR Agonist, Presenting a Special Issue on “Medicinal Chemistry: From Targets to Therapies”, Structural Approach to Assessing the Innovativeness of New Drugs Finds Accelerating Rate of Innovation, Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X, PROTAC Technology: Opportunities and Challenges, Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment, Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity, Understanding and Improving the Membrane Permeability of VH032-Based PROTACs, Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2, Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp, Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies, Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma, Fluorescence Labeling of Neurotensin(8–13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity, Eighteen 5,7-Dihalo-8-quinolinol and 2,2′-Bipyridine Co(II) Complexes as a New Class of Promising Anticancer Agents, Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors, Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. students in the field of medicinal chemistry. E-mail: [email protected], View Publication Information in Current Issue. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. You have to login with your ACS ID befor you can login with your Mendeley account. Get article recommendations from ACS based on references in your Mendeley library. Protein & Cell, Specific areas include but are not limited to: ACS Medicinal Chemistry Letters publishes: The journal also includes sections describing significant new patents and drug discovery tools. You have to login with your ACS ID befor you can login with your Mendeley account. Next vol/issue. Innovations are articles intended to tell the backstory of drug discovery campaigns relating to the development of new therapeutic agents or articles covering the discovery and development of new The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. Journal Scope. ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. You’ve supercharged your research process with ACS and Mendeley! Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry, Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources, Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response, Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic, Mechanistic drug metabolism and regulation of metabolic enzyme gene expression, Chemistry patents relevant to the medicinal chemistry field. Submission deadline: December 31, 2019. This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS), Identification of novel scaffolds for potential anti-, select article Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols, Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols, select article Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus, Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus, select article The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity, The new facile and straightforward method for the synthesis of 4, select article Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents, select article Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts, Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts, select article Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents, Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents, select article Synthesis of novel diflunisal hydrazide–hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma inhibitors, Synthesis of novel diflunisal hydrazide–hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma inhibitors, select article Cationic lipid-conjugated hydrocortisone as selective antitumor agent, Cationic lipid-conjugated hydrocortisone as selective antitumor agent, select article Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, select article Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties, select article Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities, Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities, select article Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents, Synthesis and biological evaluation of quinazolin-4(3, select article Synthesis and biological properties of prodrugs of (S)-3-(adenin-9-yl)-2-(phosphonomethoxy)propanoic acid, Synthesis and biological properties of prodrugs of (, select article Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis, Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis, select article Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype, Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype, select article Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents, Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents, select article Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents, Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents, select article Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARγ activators, Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARγ activators, select article Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase, Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on, select article Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition, Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition, select article Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition, Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition, select article Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach, Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach, select article Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside, Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside, select article Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor, Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor, select article 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors, select article Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold, select article Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties, Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties, select article O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1, O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1, select article Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors, select article (E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation, select article Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers, Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers, select article 6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase, 6-Methylpurine derived sugar modified nucleosides: Synthesis and, select article Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells, select article Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents, Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-, select article Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists, Benzamide derivatives and their constrained analogs as histamine H, select article Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives, Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives, select article Synthesis and biological evaluation of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one structural derivatives as anti-cancer and apoptosis inducing agents, Synthesis and biological evaluation of 5,10-dihydro-11, select article Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease, Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease, select article Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors, Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors, select article Combating P-glycoprotein-mediated multidrug resistance with 10-O-phenyl dihydroartemisinin ethers in MCF-7 cells, Combating P-glycoprotein-mediated multidrug resistance with 10-, select article Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes, Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes, select article Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus, Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus, select article Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors, Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1, select article In Memoriam: Professor Camille-Georges Wermuth, In Memoriam: Professor Camille-Georges Wermuth.

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